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Immunosuppression is mediated by different mechanisms, such as suppression of contact hypersensitivity (CHS), infiltration of leukocytes, DNA damage, and attenuation of antigen-presenting capacity [51]

In addition, essential fats, proteins, non-digestible carbohydrates, probiotics and polyphenols all induce shifts in the microbiome with consequences for host metabolic and immunologic markers (Reference Singh, Chang and Yan80) Therefore, attempts to investigate effects of a specific diet in a population already adhering to that diet may be of low yield and/or limited by small changes in their microbial diversity

doi: 10.1136/gutjnl-2011-301104 122 LemosB

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