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The study was not powered to assess the risk of progressive multifocal leukoencephalopathy, and 21% of patients in the extended-interval dosing group and 19% of patients in the every-4-weeks group had JCV Abs in the serum (30)

The CYP3A4 induction and inhibition assays also highlight the potential of iHLOs for dynamic pharmacological testing, a key aspect of drug safety evaluations 35

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