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Thrombopoietin receptor agonists: These medications encourage the bone marrow to increase platelet production

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GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

This activation leads to the stimulation of the VEGFR2-Akt-eNOS signaling pathway, enhancing endothelial tube formation and blood flow recovery in ischemic tissues