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Blood-brain glucose transfer in alzheimers disease: Effect of GLP-1 analog treatment
In an APP/PS1/tau mouse model of Alzheimers disease, lixisenatide reduced tau neurofibrillary tangles, amyloid- plaques and neuroinflammation, as indicated by decreased microglial activation in the hippocampus [96]
Activation of GLP-1R also enhances the levels of anti-inflammatory cytokines like IL-4 and IL-10, along with increasing the expression of the neuroprotective factor -endorphin in microglia [112]
1083) permitting psilocybin research in that state
Heppner et al., 2015)
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