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Isolation and culture of lung fibroblasts Lung tissue of former smokers (defined as quitting smoking for at least one year before surgery) with normal lung function or GOLD stage IV COPD was obtained from patients undergoing surgery for resection for pulmonary carcinoma or lung transplantation

Reactive oxygen species (ROS) include superoxide hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH ), hydroxyl ion (OH ), and hypochlorite ion (OCl )

Phytochemistry 39, 457458

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Given that ferroptosis involves non-apoptotic pathways culminating in compromised cell membrane integrity, it is hypothesized that ferroptosis significantly contributes to PA-induced cytotoxicity and may account for this apparent difference between assays measuring distinct cellular endpoints