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J Inorg Biochem 219:111431
Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding
Importantly, these spatially defined architectures are tightly coupled to local metabolic conditions within the TME
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The entire process creates a feedback loop where testosterone levels signal back to the hypothalamus and pituitary, either increasing or decreasing hormone production as needed
