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Description
A two-hit theory explains the mechanism of NASH pathogenesis, wherein simple fat accumulation in the hepatocytes (first hit) converts to lipotoxicity (second hit) with increased levels of free fatty acids, cholesterol and other lipid metabolites (Prez-Carreras et al., 2003

Young, P., Finn, B
[DOI] [PubMed] [Google Scholar] 40.Shakeri A., Tabibi H., Hedayati M

Thompson, BW

Yes, tirzepatide is approved for type 2 diabetes management

doi: 10.1038/s41598-020-76109-y 31 JiaW.LiY.CheungK
