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& Madani, A

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Nonalcoholic fatty liver disease has become one of the hepatic diseases of greatest interest recently due to its epidemiological impact, with impressive clinical and physiopathologic advances and more profound knowledge about its mechanisms that lead to persistent fibrosis, which is intimately related with NRF-2

In different ways, they all lead to a deficient activity of methionine synthase: decreased function of the enzyme protein itself (cblG

The trial was registered with the Iranian Registry of Clinical Trials on 25/12/2019 ( registered code: IRCT20120718010333N5)

doi: 10.1136/bmjgh-2020-004128 183 SalechF.PonceD