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As the MID domain undergoes little change in the transition to the TDMD conformation, we propose that these interactions serve as anchor points to help position the AGOmiRNAtrigger complex in an orientation suitable for the sensor domain of the opposite protomer to recognize trigger-induced conformational changes in the N and PAZ domains, and the trigger itself

Additionally, the administration of nerve growth factor (NGF) was observed to regulate neuronal growth and promote the restoration of DPN

For example, a tri-functional copper-based MOF nanozyme developed by Dong et al.not only generates ROS but also modulates the redox environment, overcoming chemotherapy resistance in CRC and providing a new therapeutic strategy for future clinical applications [101]

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Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2

doi: 10.3389/fimmu.2025.1626082 Received 09 May 2025 Accepted 17 July 2025 Published 07 August 2025 Volume 16 - 2025 Edited by Seng-Lai Tan, TFC Therapeutics, United States Reviewed by Andrew L
