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Description
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PAI-1, a serine protease inhibitor and another factor involved in the pathogenesis of stroke is produced primarily by the endothelium which directly acts as an active inhibitor of tPA and urokinase (uPA), a serine protease which is responsible for cleaving plasminogen to plasmin (Oishi, 2009)

doi: 10.18632/oncotarget.19853 101 DesantisVPotenzaMASgarraLNacciCScaringellaACiccoSet al

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doi:10.1007/s11120-005-8425-1 Drge W, Breitkreutz R