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This could include issues like trouble absorbing the vitamin, autoimmune diseases, or using certain medications for a long time

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Some improvement in symptoms may be seen within a few days to a week after starting treatment, but it can take longer for more severe symptoms to resolve

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Ilic S, Drmic D, Franjic S, Kolenc D, Coric M, Brcic L, et al