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Simultaneously, ROS oxidize the regulatory domain of PTP1B, inhibiting leptin receptor signal transduction [344], and activate the hepatic IKK/NF-B pathway, inducing lipid deposition [348]

MIF-driven activation of macrophages induces killing of intracellular Trypanosoma cruzi dependent on endogenous production of tumor necrosis factor, nitric oxide and reactive oxygen species

Among them, glutathione exists in two interconvertible forms: reduced glutathione (GSH) and its oxidized disulfide (GSSG), formed by the linkage of two GSH molecules via a disulfide bond

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Ge B, Song Y, Zhang Y, Liu X, Wen Y, Guo X

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