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Both these methylation reactions are vital for growth and cell reproduction.[9][10] Methionine, a sulfur-containing, essential amino acid, is a precursor of S-adenosylmethionine, a cofactor for one-carbon metabolism and the final methyl donor for the methylation of DNA, RNA, proteins, and phospholipids.[11] The methionine synthase plays a paramount role in the synthesis of nitrogenous bases (purines and pyrimidines) involved in the formation of DNA

Clinical studies show it can lead to elevated homocysteine and methylmalonic acid levels, markers associated with increased risk of type 2 diabetes and cardiovascular diseases

Both forms are very safe with minimal side effects

Vitamin B12 deficiency, tumor necrosis factor-alpha, and epidermal growth factor: a novel function for vitamin B12

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[1] [4] Mood changes including low mood, irritability, or anxiety can be associated with declining B12 levels, though these symptoms are non-specific and can have many causes