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One critical enzyme induced by Nrf2 is NAD(P)H quinone oxidoreductase-1 (NQO1), which detoxifies protein-bound quinone and maintains alpha-tocopherol and coenzyme Q10 in their reduced (antioxidant) states

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Concurrently, the utilization of leriglitazone and targeting of peroxisome-proliferator-activated receptor gamma may serve as efficacious strategies to improve mitochondrial function, thus offering a therapeutic avenue for FRDA [808, 811]

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