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8.2.3 Tests designed to assess tissue damage Tubular dysfunction is not necessarily associated with histopathological changes

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[2] In the presence of deoxyribonucleic acid (DNA)-damaging factors such as oxidative stress, heat shock, irradiation, and genotoxic drugs potentially leading to oncogene activation, cells stop in their proliferation programs to prevent the passing down of genetic mutations as a tumor suppressive mechanism