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A key mechanism contributing to MDR involves the energy-dependent efflux of drugs from cancer cells, leading to decreased intracellular drug concentrations and reduced efficacy

PubMed ID: 11146367 Heffernan MA et al

The trials tested oral, intravenous, and subcutaneous routes of administration at doses ranging from micrograms to 1 mg per day

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Stoneham et al

This reduction was not only accompanied by downregulation of endogenous mouse ApoE expression in the brain, but also decreased the levels of synaptic glutamate receptors, presynaptic protein -syn [89]