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Eukaryotic transcription factors (TFs) are characterized by two core functions: a DNA-binding capacity that recognizes specific sequences (e.g., cis -elements in promoters and enhancers) and a transactivation activity that recruits cofactors to modulate transcription 38,39

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Moreover, by conjugating cell-specific ligands or antigens to the LNP surfaces, RNA-LNPs can achieve explicit tissue targeting while minimizing systemic exposure

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