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Researcher Olle Johansson proposed in 2000 that mast cell degranulation is the primary mechanism underlying electromagnetic hypersensitivity. Skin biopsies from healthy volunteers exposed to two to four hours of ordinary screens showed measurable changes in cutaneous mast cells. Individuals with EMF hypersensitivity show elevated mast cell numbers, elevated histamine markers, and altered mast cell distributions compared to healthy controls. When mast cells degranulate, they release histamine, heparin, tryptase, prostaglandins, and dozens of inflammatory mediators

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