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Natural mutations in serine 225 and 280 [94] markedly reduce carnitine transport, although it is unknown whether it is related to abnormal phosphorylation

2 Structure, Distribution, and Physiological Action of the Carnitine Palmitoyltransferase System CPT1, CPT2, and carnitine-acylcarnitine translocase (CACT) play vital roles in the transport system for FA esterification in the mitochondrial membrane

Holland WL, Brozinick JT, Wang L-P, Hawkins ED, Sargent KM, Liu Y, et al

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10.1016/0022-2828(91)90019-i J

In addition, betaine can also be synthesized de novo from dietary choline in the mammalian liver and kidney via a two-step enzymatic process in which choline is first oxidized to betaine aldehyde by choline dehydrogenase