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Distribution and Metabolism of N G -nitro- L -arginine Methyl Ester in Patients with Septic Shock

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While all studies adequately ascertained exposure and ensured comparability between outcome groups by controlling for confounders, 42% (n = 5) did not provide adequate sample representativeness and size, and 17% (n = 2) did not report the non-response rate

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Across all trials, serum IGF-1 concentrations were not significantly altered by AOD-9604 exposure relative to placebo, consistent with the hypothesis that the peptide does not engage the canonical hGH receptor or stimulate downstream IGF-1 production

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