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Severe GI adverse reactions have also been reported postmarketing with GLP-1 receptor agonists

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Semaglutide: An Overview Semaglutide is a GLP-1 receptor agonist , a class of medications designed to mimic the effects of a hormone called glucagon-like peptide-1 (GLP-1)

This difference may be explained by the results of in vitro binding studies, which showed that daratumumab can directly bind CD38 on RBCs, whereas isatuximab requires a cofactor (e.g., a mouse anti-CD38 antibody or a CD38 inhibitor), suggesting masking of the isatuximab epitope on RBCs in some patients [49, 50]