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While recombination has been extensively studied, still little is known of the mechanisms behind this process

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246 In a meta-analysis of 14 randomized controlled trials including 766 participants, green coffee extract at dosages ranging from 90 to 6,000 mg/day (providing 13.5 to 1,200 mg/day CGA) for up to 16 weeks lowered serum total cholesterol

Although various factors, including chronic hyperglycemic stimuli, repeated episodic hypoglycemia and ketoacidosis, damage to the BBB, insulin dysfunction in the brain, cardiovascular risk factors, and metabolic changes, have been explored, the pathogenesis of diabetes-related cognitive impairment is still a subject of preliminary investigation