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Microbiome-based therapeutics and clinical translation Microbiome-based therapeutics have evolved from empirical FMT to rationally engineered interventions, including defined microbial consortia, genetically modified strains, prebiotics, and phage therapies (Mimee et al., 2016

Single-genotype cohort According to the Abbott RT-PCR, for the single-GT cohort -which included 114 patients- the most commonly identified GT was 1b accounting for 37% (42 out of 114) of all samples, followed by GT 4, which accounted for 25% (29 out of 114)

Clinical and biological implications Taken together, the findings support the concept that ASD is associated with selective metabolic perturbations that may be amenable to dietary modulation