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doi: 10.1016/j.chom.2022.05.005 149 TeubnerW.MeinlW.FlorianS.KretzschmarM.GlattH

Inherited Disorders of the -Glutamyl Cycle At least two genetic enzyme defects lead to the overproduction of 5-oxoproline

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In this search, several important secondary sources were identified which have been helpful for the design of this systematic review and for writing the introduction section

Repressive histone marks suppress genes from other lineages (neuronal, oligodendrocyte), maintaining astrocyte specificity in the context of embryonic neurogenesis, adult neurogenesis, neurodegenerative (e.g., HDAC2, HDAC6, CBP/p300, MLL1/3/4, SETD1A/B, SIRT1 and others in AD

In contrast, ATF4 mainly drives CHAC1 transcription under stress conditions through its interaction with both the ATF/CRE and ACM motif ( In addition to ATF4, CHOP plays a critical role in regulating CHAC1 during UFR ( CHAC1 promoter