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Quinone-induced oxidative stress elevates glutathione and induces -glutamylcysteine synthetase activity in rat lung epithelial L2 cells

10.1016/j.burns.2018.04.015 Burns

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Inject slowly: Push the plunger down slowly and steadily until the full dose is delivered

Neuronal GSH production is believed to be primarily mediated by astrocytic GSH release, and astrocytic GSH production is rate-limited by cysteine and the enzyme glutamatecysteine ligase.4,5 In addition to providing cysteine for GSH production, NAC has been shown to scavenge oxidants directly, particularly the reduction of the hydroxyl radical, OH and hypochlorous acid.6 Oral administration of GSH alone does not adequately restore GSH levels