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& Moreira, P

DNA damage can make PARP1 use up to 80% of the NAD+ in the nucleus

Benefits: Chronic illness or infections Oxidative stress Antioxidant Cell / tissue repair & regeneration Immune system support *Some blood testing may be required

Telomere length and brain aging: A systematic review and meta-analysis

Focusing on a fundamental process like redox balance, GR inhibitors may offer a distinct mode of action compared to traditional antibiotics, thereby reducing the risk of cross-resistance

The secondary outcomes will be the serum vitamin B12 concentration (pg/ml), adverse events (description, moment of onset and resolution, intensity, cause, steps taken), adherence to treatment (measured at each patient visit via the number of vials used for patients in the oral arm, and the number of injections given in the intramuscular arm), quality of life (measured using the EuroQoL-5D questionnaire), and patient satisfaction and preferences