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Until human clinical data are published, users should follow expert recommendations and prioritize professionally supervised dosing
[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Costain AH, MacDonald AS, Smits HH
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This multi-guide strategy increases the likelihood of inducing frameshifts or deletions that produce a functional knockout, offering a more robust alternative to single-guide approaches

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doi: 10.1002/cncr.24597