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(2011), investigating the Nrf2 modulation effects of fish oil and lycopene in the context of prostate cancer risk, also demonstrated that these dietary compounds can upregulate Nrf2 signaling and response to oxidative stress in humans [181]

doi: 10.1006/bbrc.1999.0255 53 HataMAndriessenEMMAHataMDiaz-MarinRFournierFCrespo-GarciaSet al

Superoxide anion radical (O 2 ) is the primary cell-generated ROS which triggers a cascade of reactions and, therefore, the formation of secondary ROS, either directly or via enzymatic and metal-catalyzed processes, counting on the cell compartment

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[DOI] [Google Scholar] 51.Du J., Cullen J.J., Buettner G.R

Studies have determined that compared with primary breast cancer, the degree of pyruvate carboxylase (PC)-dependent anaplerosis in lung metastasis of breast cancer is higher, as a result of responding to the lung microenvironment (116)