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We observed decreased levels of 3,4-hydroxyphenyl lactate in RTT

To date, most studies have been cross-sectional nature ( Table 1 )

1 In veterinary medicine, it can be used as an adjunctive treatment for canine dilated cardiomyopathy, with 90% of dogs suffering from this disease showing symptoms of carnitine deficiency

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The positron emission tomography (PET) was used to examine brain oxygen consumption and cerebral blood flow and revealed that patients with overt hepatic encephalopathy and those with liver cirrhosis without overt hepatic encephalopathy had a lower cerebral metabolic rate of oxygen and cerebral blood flow than healthy subjects 4

At the same time, LC is thought to down-regulate the expression of oxidative-stress-related genes such as Bax, Bcl-2, and caspase-3 [32]