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The Peptide Mechanisms That Target Venous Wall Integrity Venous insufficiency and varicose vein formation fundamentally involve three overlapping pathological processes: endothelial dysfunction (the inner lining of veins loses its barrier function and regulatory capacity), extracellular matrix degradation (collagen and elastin fibers that give vein walls structural strength break down faster than they're replaced), and chronic low-grade inflammation that compounds both problems

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The RECOVER study, published in 2025, highlighted that ME/CFS diagnoses have increased significantly since the COVID pandemic, with many long COVID patients now meeting ME/CFS criteria (Vernon et al., 2025)

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