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Although pentosan polysulfate is an approved treatment for interstitial cystitis, some patients on this medication experience treatment failure after one year, and its long-term use has been linked to pigmentary maculopathy
The most effective agents for ameliorating the onset and progression of cardiovascular diseases are antioxidants

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Combination anti-TNF-alpha and thiopurine therapy increases the risk of serious opportunistic infections and hepatosplenic T-cell lymphoma
