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OTA dramatically alleviates the mRNA level of Nrf2 as well as GCL and GST levels in LLCPK1 cells.152 There are several potential mechanisms for OTAinduced Nrf2 inhibition: (a) blocking nuclear import of Nrf2

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In case of autoimmune components, auto-antibodies directed at fetal brain proteins might cause BBB damage (Zimmerman et al., 2007)

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