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Additional investigations are warranted to ascertain the suitability of NNMT as a therapeutic target for MetS

Studies have consistently reported that inhibiting NNMT activity or downregulating NNMT expression leads to significant increases in NAD + levels in mouse adipocytes (Neelakantan et al., 2018) and hepatocytes (Song et al., 2020)

Activating these receptors triggers a signaling cascade that upregulates hormone-sensitive lipase, which breaks down stored triglycerides into free fatty acids and glycerol essentially mobilizing stored fat for use as energy

Some patients find taking a deep breath and exhaling slowly while inserting the needle helps manage anxiety, while others prefer distraction techniques like watching TV during the process

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