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Arch Intern Med 165: 1167-1172

3.3.1 Mitochondrial fusion and regulatory mechanisms Mitochondrial fusion is a cellular self-repair mechanism that combines healthy mitochondria with damaged or mutated mitochondria to repair the damage or compensate for the mitochondrial dysfunction caused by mutations through complementary effects, thus ensuring normal mitochondrial function and maintaining normal cellular physiological activities (Twig and Shirihai, 2011)

They are synthesized predominately in myeloid cells and are stored in secretory granules of neutrophils

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