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Biologically important thiol-disulfide reactions and the role of cyst(e)ine in proteins: An evolutionary perspective

Besides, another study published in Chinese Medicine explored the effects of Cucurbitacin B on inhibiting transforming growth factor-beta 1 (TGF- 1)-induced epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC), revealing that Cucurbitacin B modulates ROS production and the phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) signaling pathways [17]

The same was observed by Sahamoto et al

These results suggest that compounds able to buffer GSH decrement could be promising candidate drugs to prevent or treat the onset and progression of inflammatory condition/diseases (i.e., aging, atrophy, cachexia, sarcopenia)