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The 5xFAD transgenic mouse line has been genetically engineered to model features of AD through the expression of human amyloid precursor protein (APP) and presenilin-1 transgenes, which are associated with earlyonset AD [21]
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an inhibitor of IGF-I action ( Figure 2 )
Deuschl G, Schade-Brittinger C, Krack P, et al
