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Increases in genes associated with cytokine pathways, antigen presentation, the complement cascade, and reactivity [e.g., glial fibrillary acidic protein ( Gfap )] were observed in astrocytes in the hippocampus, hypothalamus, visual cortex, striatum and cerebellum of aged mice (24-months-old

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Purified ferritin from glioblastoma-derived cell line has marked apoptosis-stimulating activity and are inhibited by neutralizing anti-ferritin antibody Ab rH02, however, isoferrin released from cultured neonatal astrocytes did not show this activity, suggesting that the transition of astrocytes to a malignant phenotype is accompanied by alterations in iron metabolic processes (26)

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