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In a phase 2 study involving 21 patients with recurrent rGB, anlotinib combined with temozolomide demonstrated efficacy, achieving a median progression-free survival (PFS) of 7.3 months and a median overall survival (OS) of 16.9 months ( Regorafinib, a pankinase inhibitor, was initially tested as monotherapy on rGB patients in a phase 2 trial, which showed a survival benefit when compared to CCNU ( 3 CDK-Rb targeting agents Targeting this pathway in oncology has been primarily limited to CDK4/6 inhibitors

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Gupte SA, Levine RJ, Gupte RS, Young ME, Lionetti V, Labinskyy V, Floyd BC, Ojaimi C, Bellomo M, Wolin MS, and Recchia FA

It consists of two main subtypes: anti-apoptotic proteins like Bcl-2, Bcl-XL, and Bcl-w, and pro-apoptotic proteins, which include BAK, BAX, BOK, and BH3-only proteins (201)

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The peptide integrity is verified at 96.5% via HPLC-MS
