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First, CO exhibits cytoprotective properties in vascular endothelial cells by inhibiting apoptosis, likely through activation of p38 mitogen-activated protein kinase (MAPK) signaling pathway (Brouard et al., 2000), decrease macrophage toll-like receptor (TLR) signaling with downstream activation of NF-kB (Wang et al., 2009) and inhibit expression of GM-CSF with probable alteration of macrophage differentiation (Sarady et al., 2002)

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These complications signal the need to conduct more research regarding optimizing formulations and bioavailability to help women with PCOS to better manage their conditions (57, 58)

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