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Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 19992006

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With the exception of C159S and Y296A, this event is very rapid with estimated observed rate constants of 1000 s s 1 , and for this reason a large portion of the flavin reduction phase is generally obscured in the deadtime of the stopped-flow instrument