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Description

Apoptosis, characterized by chromatin condensation, fragmentation and internucleosomal DNA cleavage, and necrosis, characterized by rupture or fragmentation of the plasma membrane and ATP depletion [32] can coexist and share common pathways, such as involvement of the mitochondria [33]

The mitophagy activator urolithin A is safe and induces a molecular signature ofimproved mitochondrial and cellular health in humans

The NRF2 pathway is activated in the setting of acute inflammation and functions to reduce excessive tissue damage by tampering the acute cytotoxic effects of the innate immune response

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