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In contrast, chronic or diabetic wounds often exhibit metabolic disturbances that are potentially characterized by excessive glycolysis coupled with suppressed oxidative phosphorylation or mitochondrial dysfunction, resulting in insufficient energy metabolism and exacerbated inflammatory responses

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Several Cereblon-based PROTACs containing ether-linked 4-hydroxythalidomide derivatives have been reported in scientific literature (Table 6)

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Howe CL, et al

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2003, 22 (6): 497-10.1002/humu.9199