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A key mechanism involved in such resistance is the sustained activation of NRF2, a key regulator of ferroptosis evasion in tumor cells [20, 21]

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Free Radic Biol Med 42:617626 de Bernardo S, Canals S, Casarejos MJ, Solano RM, Menendez J, Mena MA (2004) Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures

N-Acetyl Cysteine, commonly referred to as NAC, is a derivative of the amino acid cysteine

All cells were routinely supplemented with 10% fetal bovine serum (FBS), 1% penicillin/streptomycin, and 2% L-glutamine