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Pharmacological inhibition of XO (e.g., allopurinol) demonstrates marked hypouricemic effects, underscoring the clinical significance of this pathway (Yang et al., 2024)

Dietary patterns are increasingly recognized as modifiable risk factors for PD, acting through mechanisms such as oxidative stress, chronic inflammation, and gut microbiota dysregulation [98]

Importantly, FOXO3 is also a critical regulator of NFkB activity

As viscosity is a measure of the ability of mucus to disperse energy and prevent flow, mucus that is too viscous can flatten the delicate cilia under the osmotic pressure and weight such that their waveform is ineffective or entirely blocked (Liu et al., 2014