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A primary consideration is the tradeoff broad-spectrum senolytic effect and the negative effects on normal proliferating cells, due to the lack of clearly defined boundaries between senescent and cells undergoing milder, but non-senescence-inducing stresses, or even non-senescent cells that express markers of senescence

Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions

Nanoparticle-delivered peptides One of the challenges with peptide therapies is delivery

Traditional management often involves antibiotics, dietary changes, and in severe cases, surgery

Intervention study While the studies cited above are largely consistent with the existence of a high-folatelow-vitamin B-12 interaction affecting both tHcy and MMA metabolism, data are limited on the effect of high-dose folic acid supplements on these 2 biomarkers in vitamin B-12deficient individuals

Peter Paul de Deyn for access to the human brain materials (NeuroBiobank)