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J Biol Chem 263: 64476453, 1988

TZDs activate PPAR to promote adipogenesis and fatty acid uptake, increase glucose utilization and decrease glucose production, and subsequently enhance insulin sensitivity by upregulating genes involved in lipid metabolism, such as CD36, FABP4 , and LPL (395)

These findings emphasize the importance of proper nutritional and metabolic management during late gestation and suggest that L-carnitine supplementation could be an effective strategy in improving follicular health and reproductive performance in ewes with SPT, including pregnancy rate, lambing rate, and litter size

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Bostrm P et al (2012) A PGC1-dependent myokine that drives browning of white fat and thermogenesis

Unfortunately, this narrow therapeutic window is often missed