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Homologous recombination deficiency (HRD) caused by BRCA1/2 gene mutations leads to resistance to platinum-based chemotherapeutic agents, a phenomenon particularly evident in HGSOC ( The Homologous Recombination Deficiency (HRD) Score is a tool for predicting cancer patients' chemotherapy responses by assessing genomic instability (93)

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It plays a key role in protecting neurons from oxidative stress, supporting cognitive performance, and helping slow age-related cognitive decline

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