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Overall, ligand specificity for LPL would then be conferred by a combination of the lid peptide, hydrophobic pocket, and hydrophobic pore

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A study with 3,224 participants found that low choline intake was associated with an increased risk of incident dementia and Alzheimers disease (136)

doi: 10.1055/s-2007-978596

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4.1.1 NHR-49 has tissue specific roles in regulating longevity As noted above, when expressed from its own promoter, nhr-49 is sufficient to extend lifespan, and such overexpression also rescues the short lifespan of nhr-49(nr2041) mutants (Ratnappan et al., 2014)