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For example, dietary methionine restriction (MR) in combination with PD-1 blockade increases the abundance of tumor-infiltrating CD8+ T cells and enhances granzyme B expression

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These channels define the pore pathway 47 (Box 1) and are exemplified by claudin-2, which mediates paracellular flux of small cations, such as Na + , and water 42,43,48,49

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Gaspar et al., 2018