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The role of mitochondria in eosinophil function: implications for severe asthma pathogenesis

For example, an acute inflammatory response drives the transcription factor, NFB, to switch melatonin synthesis from pinealocytes to macrophages/microglia and, upon acute inflammatory resolution, back to pinealocytes

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and stage 3 (compounding prevalence), where the incidence decelerates, plateaus or declines while the prevalence steadily increases

While mutation in GLYI and D-LDH accumulation would lead to higher accumulation of MG and D-lactate, respectively

Yang et al., 2014)